An evaluation of the relationship between self-esteem and pet bonding in children

Obesity has been linked to many physical as well as psychological problems. Many children who are obese suffer from low self-esteem. No studies have been published documenting the effect of owning a dog on the self-esteem of children who are obese. This study used a non-experimental, descriptive, four-group comparison design. One-hundred-twenty participants comprised the four groups: obese children with a dog, obese children without a dog, children of a healthy weight with a dog, and children of a healthy weight without a dog. Participants who were in the 85th percentile or higher for their height and weight were placed in the obese group. All participants completed the Self-Perception Profile for Children (SPPC) and participants who owned a dog that lived in the house at least 50% of the time also completed the Pet Bonding Scale (PBS). The four groups were similar on most demographic characteristics. Obese children had lower scores in the domains of Physical Appearance, Social Competence, and Self-Worth. Participants in the study who owned a dog, both obese and of a healthy weight, were more likely to have lower Physical Appearance and Behavioral Conduct scores. All 60 participants in this study who owned a dog considered the dog to be a member of their family. The findings of this study can be used as the basis for future studies evaluating the relationships between dog ownership of obese children and effects on self-esteem

Critical review of the impacts of grazing intensity on soil organic carbon storage and other soil quality indicators in extensively managed grasslands

Acknowledgements This work contributes to the N-Circle project (grant number BB/N013484/1), and CINAg (BB/N013468/1) Virtual Joint Centres on Agricultural Nitrogen (funded by the Newton Fund via UK BBSRC/NERC), U-GRASS (grant number NE/M016900/1), the Belmont Forum/FACCE-JPI DEVIL project (grant number NE/M021327/1), Soils-R-GGREAT (grant number NE/P019455/1), ADVENT (grant number NE/M019713/1), Sêr Cymru LCEE-NRN project, Climate-Smart Grass and the Scottish Government’s Strategic Research Programme.Peer reviewedPublisher PD

A survey of diffuse interstellar bands in the Andromeda galaxy: optical spectroscopy of M31 OB stars

We present the largest sample to-date of intermediate-resolution blue-to-red optical spectra of B-type supergiants in M31 and undertake the first survey of diffuse interstellar bands (DIBs) in this galaxy. Spectral classifications, radial velocities and interstellar reddenings are presented for 34 stars in three regions of M31. Radial velocities and equivalent widths are given for the 5780 and 6283 DIBs towards 11 stars. Equivalent widths are also presented for the following DIBs detected in three sightlines in M31: 4428, 5705, 5780, 5797, 6203, 6269, 6283, 6379, 6613, 6660, and 6993. All of these M31 DIB carriers reside in clouds at radial velocities matching those of interstellar Na I and/or H I. The relationships between DIB equivalent widths and reddening (E(B-V)) are consistent with those observed in the local ISM of the Milky Way. Many of the observed sightlines show DIB strengths (per unit reddening) which lie at the upper end of the range of Galactic values. DIB strengths per unit reddening are found (with 68% confidence), to correlate with the interstellar UV radiation field strength. The strongest DIBs are observed where the interstellar UV flux is lowest. The mean Spitzer 8/24 micron emission ratio in our three fields is slightly lower than that measured in the Milky Way, but we identify no correlation between this ratio and the DIB strengths in M31. Interstellar oxygen abundances derived from the spectra of three M31 H II regions in one of the fields indicate that the average metallicity of the ISM in that region is 12 + log[O/H] = 8.54 +- 0.18, which is approximately equal to the value in the solar neighbourhood

National Evaluation of the Capacity Building Programme in English Local Government: Evaluation of the National Programmes: Annex 2: Evaluation of the National Programmes

The report is one of a series of outputs from the national evaluation of the CBP, being undertaken by a team of researchers at the Policy Research Institute (PRI) at Leeds Metropolitan University and the Cities Research Unit at the University of West of England. The Capacity Building Programme for local government was launched in 2003 as a joint Department for Communities and Local Government (DCLG) / Local Government Association (LGA) initiative to support capacity building and improvement activities within local authorities in England. The evaluation of the Capacity Building Programme has been underway since late 2004. A scoping phase was conducted until May 2005, including a short evaluation of the Pilot Programmes. The main phase of the evaluation commenced in September 2005 and encompassed four main phases (see Section 1.3: p10)

A coupled drug kinetics-cell cycle model to analyse the response of human cells to intervention by topotecan

A model describing the response of the growth of single human cells in the absence and presence of the anti-cancer agent topotecan (TPT) is presented. The model includes a novel coupling of both the kinetics of TPT and cell cycle responses to the agent. By linking the models in this way, rather than using separate (disjoint) approaches, it is possible to illustrate how the drug perturbs the cell cycle. The model is compared to experimental in vitro cell cycle response data (comprising single cell descriptors for molecular and behavioural events), showing good qualitative agreement for a range of TPT dose levels

Noninfectious retrovirus particles drive the APOBEC3/Rfv3 dependent neutralizing antibody response.

Members of the APOBEC3 family of deoxycytidine deaminases counteract a broad range of retroviruses in vitro through an indirect mechanism that requires virion incorporation and inhibition of reverse transcription and/or hypermutation of minus strand transcripts in the next target cell. The selective advantage to the host of this indirect restriction mechanism remains unclear, but valuable insights may be gained by studying APOBEC3 function in vivo. Apobec3 was previously shown to encode Rfv3, a classical resistance gene that controls the recovery of mice from pathogenic Friend retrovirus (FV) infection by promoting a more potent neutralizing antibody (NAb) response. The underlying mechanism does not involve a direct effect of Apobec3 on B cell function. Here we show that while Apobec3 decreased titers of infectious virus during acute FV infection, plasma viral RNA loads were maintained, indicating substantial release of noninfectious particles in vivo. The lack of plasma virion infectivity was associated with a significant post-entry block during early reverse transcription rather than G-to-A hypermutation. The Apobec3-dependent NAb response correlated with IgG binding titers against native, but not detergent-lysed virions. These findings indicate that innate Apobec3 restriction promotes NAb responses by maintaining high concentrations of virions with native B cell epitopes, but in the context of low virion infectivity. Finally, Apobec3 restriction was found to be saturable in vivo, since increasing FV inoculum doses resulted in decreased Apobec3 inhibition. By analogy, maximizing the release of noninfectious particles by modulating APOBEC3 expression may improve humoral immunity against pathogenic human retroviral infections

Unveiling the nature of IGR J16283-4838

Context. One of the most striking discoveries of the INTEGRAL observatory is the existence of a previously unknown population of X-ray sources in the inner arms of the Galaxy. The investigations of the optical/NIR counterparts of some of them have provided evidence that they are highly absorbed high mass X-ray binaries hosting supergiants. Aims. We aim to identify the optical/NIR counterpart of one of the newly discovered INTEGRAL sources, IGR J16283-4838, and determine the nature of this system. Methods. We present optical and NIR observations of the field of IGR J16283-4838, and use the astrometry and photometry of the sources within it to identify its counterpart. We obtain its NIR spectrum, and its optical/NIR spectral energy distribution by means of broadband photometry. We search for the intrinsic polarization of its light, and its short and long-term photometric variability. Results. We demonstrate that this source is a highly absorbed HMXB located beyond the Galactic center, and that it may be surrounded by a variable circumstellar medium.Comment: 6 pages, 5 figures, accepted for publication in Astronomy & Astrophysic